WIT Press


Composite Model Of A Hematopoietic System With Clone Competition

Price

Free (open access)

Paper DOI

10.2495/CMEM130061

Volume

55

Pages

9

Page Range

69 - 77

Published

2013

Size

473 kb

Author(s)

M. Rusinov, S. Kulikov & L. Uvarova

Abstract

This paper is dedicated to the development of a human hematopoietic system model, its identification and investigation of the roles of polyclonal and complex feedback in defining the behaviour of the system. The main purpose of the model framing is the study of the interaction and the possible pathogenetic role of simultaneously coexisting distinct lines of blood, which develop in parallel. The article proposes a classification system for human hematogenesis models based on following a key principle: the method of describing the age structure of cell population. Based on the analysis of said classification certain system features, which have not been considered previously, stand out. To take them into account, we propose a model based on the McKendrick–von Foerster equation. This paper describes the features and limitations of this model and discusses further development of the model Keywords: mathematical model, hematopoietic system, stem cell, hematopoiesis.

Keywords

Keywords: mathematical model, hematopoietic system, stem cell, hematopoiesis.