WIT Press


Kinetic And Modeling Of Radiolytic Decomposition Of Antibiotics

Price

Free (open access)

Paper DOI

10.2495/WM080051

Volume

109

Pages

9

Page Range

39 - 47

Published

2008

Size

445 kb

Author(s)

S. Yu, D. Choi & M. Lee

Abstract

There has been recent growing interest in the presence of antibiotics in different environmental compartments. One considerable concern is the potential development of antibiotic-resistant bacteria in the environment, even at low concentrations. Kinetic experiments were conducted to compare two kinetic models for radiolytic decomposition of various antibiotics such as cephradine, amoxicillin, sulfamethazine, tetracycline, and lincomycin. Batch kinetic experiments with initial aqueous concentrations of 2, 6, 8, 20 mg/L showed the decomposition of antibiotics using gamma radiation followed a pseudo first-order reaction, and the dose constant increased with lower initial concentrations. For comparison of a kinetic model for radiolytic decomposition of various antibiotics, the Monod equation was used. The kinetic parameters of maximum reaction rates (kmax) and half-velocity coefficient (Ks) are obtained. The kmax values ranged from 0.29 to 0.99 µM/Gy. The Ks values for antibiotics decreased in the order of: cephradine > lincomycin > amoxicillin > sulfamethazine > tetracycline. Radiolytic decomposition of antibiotics by gamma radiation was well described by both a pseudo first-order reaction and the Monod equation. Keywords: radiation, antibiotics, kinetics, modeling. 1 Introduction Reports in the literature show that pharmaceuticals used in human and animal husbandry are present in soil, sediment, surface water, and groundwater. As important pharmaceuticals in today’s medicine, antibiotics are used mainly to prevent and treat human and animal diseases, as well as for growth promoters in

Keywords

radiation, antibiotics, kinetics, modeling.