A Mathematical Model To Predict The Performance Of Advanced Therapies In Wound Healing
Free (open access)
235 - 246
J. Ko, S. Dickman & V. W. Li
Wound healing is a complex, dynamic process. The ability to simulate this process using mathematical models that incorporate quantitative data on growth factors, tissue repair cells and matrix components would be a powerful tool to predict, analyze, and optimize new therapies. We present such a mathematical framework based on a system of ordinary differential equations and wound healing parameter values fromthe established literature. In contrast to conventional therapy, advanced modalities can augment certain components of the healing process in a measurable fashion. The performance of specific wound therapies can be simulated and compared to other therapies.We have enhanced the model by incorporating parameters of clinical practice used in the real world setting. This approach has application to predictive performance analysis and optimization of new advanced modalities and determination of best clinical practice. Keywords: wound healing, differential equations, bifurcation.
wound healing, differential equations, bifurcation.