Microvascular Disorders Induced By Malaria Infected Red Blood Cells: A Computational Mechanical Study Using The Biological Particle Method
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T. Yamaguchi, H. Kondo, Y. Imai & T. Ishikawa
We simulated malarial microvascular blood flow disturbances by using a new particle method of biological solid-fluid interaction analysis especially developed for the analysis of malaria infection. Particle based spatial discretization and the sub time step time integration could provide us with stable computations for micro scale blood flow involving interaction with many cells. We performed numerical simulation of the stretching of infected red blood cells and the results agreed well with experimental results. Our model successfully simulated the flow of infected red blood cells into narrow channels. Keywords: malaria, computational fluid dynamics, particle method, red blood cell, microcirculation, mechanical properties of cell membrane.
malaria, computational fluid dynamics, particle method, red blood cell, microcirculation, mechanical properties of cell membrane.