Author(s)

M. E. Zeman, J. M. Garcia, M. Cerrolaza & M. Doblaré

Abstract

Bone remodelling considering drug effects on a damage mechanics model M. E. ema an', J. M. ~ a r c i a ~ , M. ~errolaza' & M. ~ o b l a r e ~ 1 Bioengineering Centre, Faculty of Engineering, Central Universi~ of Venezuela 2,Structural Mechanics Division, Mechanical Eng. Dep. Centro Politecnico Superior, Universiiy of Zaragoza, Spain Abstract It is well known that mechanical loads are one of the main factors that affect bone remodelling process. This phenomenon is widely applied to the study of prosthetic replacement, for example hip prosthesis. Elderly people are the most common patient to receive a hlp replacement surgery. Alendronate is a drug that is being used to increase bone mineral content in patients with poor bone quality. This work uses a mechanical model based on damage mechanics, which considers bone's porosity as the damage variable, a mechanical stimulus associated thermodynamically to this variable, a damage criterion and an evolution damage law. Our approach simulates the degre

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