Author(s)

B. Kogan, J. Better & I. Zlochistyy

Abstract

The cardiac cell model at normal and high pacing rates with Markovian representations of gating processes (Computer simulation study) B. Kogan, J. Better & I. Zlochistyy Computer Science Department, University of California, Los Angeles, California, USA Abstract Over the past years significant results have been achieved in the mathematical modeling and computer simulation of action potential generation and propagation using Hodgkin-Huxley formalism. The development of the single channel clamp experiment technique has provided new experimental data, and also led to a Markovian formulation of the ion channels gating processes. The advantages of this formulation are: it makes the artificial Hodgkin-Huxley assumption of mutual independence of gating processes unnecessary and also opens the possibility of simulating the effects of drugs, toxins and genetic defects in channel proteins on the behavior of cardiac cells. The comparison of the effect of Markovian and Hodgkin-Huxley representations for

Keywords