Author(s)

M. Jelenc, T. Podnar, F. Runovc & M. Kordaš

Abstract

Advanced cardiovascular physiology studied by applying the equivalent electronic circuit M. ~elenc', T. ~odnar', F. RU~OVC' and M. ~ o r d a ~ ~ i University Hospital of'Puedia~ric.r, Ljubljana, Slovenia ' ~ a c u l t ~ of Natural Science and Engineering, Ljubljana, Slovenia 3 Institute qf Pathophysiology, Ljubljana, Sloveniu Abstract The equivalent electronic circuit, developed to simulate cardiovascular physiology, is upgraded to incorporate negative feed-back loops. In this way homeostasis of the arterial pressure is simulated in left ventricular failure both if the feed-back loops are disconnected from, or connected to, their target organs. The results show that in left ventricular failure homeostasis strongly supports the cardiovascular system both by modulating Starling mechanism(s) of the heart and by modulating the tone of the venous system. 1 Introduction There are various approaches in modelling methodology for physiology and medicine (reviewed in [l]). However, recently it has been

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