Author(s)

G. M. Saidel, J.A. DiBella II & M. E. Cabrera

Abstract

Metabolic system dynamics: lumped and distributed models G.M. aid el''^, J.A. DiBella 11' & M.E. ~ a b r e r a " ~ ' ~ I Department of Biomedical Engineering, Case Western Reserve University Cleveland, OH, USA 2 Center for Modeling Integrated Metabolic Systems Case Western Reserve University 3 Department of Pediatrics, Rainbow Babies and Children's Hospital University Hospitals of Cleveland Abstract A quantitative understanding of the complexity of cellular metabolism integrated within a tissue-organ system requires mathematical modeling and simulation. Physiologically based dynamic models that incorporate cellular metabolic reactions and transport processes of many chemical species may be spatially lumped andlor distributed. Such models allow quantitative evaluation of metabolic pathways and regulatory mechanisms under normal and abnormal conditions. In our Center for Modeling Integrated Metabolic Systems (MIMS), we are developing a general integrative whole-body model that relates cellular

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