Author(s)

T. Martonen, D. Hwang & J. Fleming

Abstract

Integration of computer model of drug delivery with human subject testing T. art on en', D. wan^^ & J. ~ l e r n i n ~ ~ I National Health and Environmental Effects Research Laboratory, Research Triangle Park, and Department of Medicine, University of North Carolina, USA 2 IBM, Research Triangle Park, USA 3~outhampton General Hospital, UK Abstract Mathematical models may be used a priori to determine experimental conditions to facilitate the administration of inhaled pharmacologic drugs. By regulating inhaled particle sizes and patient ventilatory parameters, aerosolized medicines can be targeted to appropriate sites to elicit optimum therapeutic effects. In our clinical laboratory we have employed computer simulations as a methodology to treat respiratory diseases per se, and are presently advocating inhalation as a novel technique for systemic delivery of pharmaceuticals to other organs. In both types of models, it is imperative that the morphology of the human respiratory system be anatomi

Keywords