WIT Press


Thread As A Substrate For Low-cost Point-of-care Diagnostics

Price

Free (open access)

Paper DOI

10.2495/CHEM110221

Volume

154

Pages

12

Page Range

233 - 244

Published

2011

Size

717 kb

Author(s)

X. Li, D. Ballerini, J. Tian & W. Shen

Abstract

This study presents new applications of thread-based microfluidic systems in chemical and biochemical diagnostics. Our recent reports have demonstrated the capability of fabricating low-cost microfluidic devices using ubiquitous multifilament materials such as threads. The gaps between fibres in threads provide capillary wicking channels for liquid transport; therefore, liquid can penetrate along threads without the need of external forces. The new threadbased system, combined with the cheap dosing tools, is capable of easily and rapidly semi-quantifying the concentration of analytes in human body fluids. The utility of this system is further extended for the rapid and easy blood grouping with only small amount of whole blood (~ 2 μL for ABO blood typing), which is an essential test before blood transfusion. These low-cost and portable microfluidic devices are easy to fabricate, simple to use, and do not require powers such as electricity; thus providing a desirable analytical platform for point-of-care applications. Keywords: low-cost diagnostics, microfluidic, point-of-care, thread-based. 1 Introduction Modern microfluidic systems have been designed to carry out complicated analytical measurements for a range of applications [1]. However, such sophisticated microfluidic systems are usually expensive and the users always need to be trained to acquire the operation skills, thus restricting the practicability of these systems. The increasing needs of low-cost microfluidic devices which are readily accessible to average users, especially those people from under-developed areas or remote regions compel the development of new

Keywords

low-cost diagnostics, microfluidic, point-of-care, thread-based