WIT Press


Propagation Of Electrical Excitation In A Ring Of Cardiac Cells: A Computer Simulation Study

Price

Free (open access)

Paper DOI

10.2495/BSIM960281

Volume

3

Pages

11

Published

1996

Size

984 kb

Author(s)

B.Y. Kogan, W.J. Karplus, M.G. Karpoukhin, I.M. Roizen, E. Chudin & Z. Qu

Abstract

The propagation of electrical excitation in a ring of cells described by the Noble, Beeler-Reuter (BR), Luo-Rudy I (LR I), and third-order simplified (TOS) mathematical models is studied using computer simulation. For each of the models it is shown chat after transition from steady-state circulation to quasi-periodicity achieved by shortening the ring length (RL), the ac- tion potential duration (APD) restitution curve becomes a double-valued function and is located below the original ( that of an isolated cell) APD restitution curve. The distributions of APD and diastolic interval (DI) along a ring for the entire range of RL corresponding to quasi-periodic oscillations remain periodic with the period slightly different from two RLs. The "5" shape of the o

Keywords