WIT Press

The Use Of Perfluorochemical Liquid As An Alternative Method To Traditional Mechanical Ventilation

Price

Free (open access)

Paper DOI

10.2495/BIO950741

Volume

2

Pages

8

Published

1995

Size

623 kb

Author(s)

M. L. Constantino

Abstract

Over the last years, results of physiological studies in both adult and premature animals have demonstrated that ventilation with an oxygenated perfluorochemical (PFC) liquid provides effective gas exchange and acid-base balance and improves lung function and recovery. Perfluorochemical liquids are biologically inert and non-biotransformable substances. The low surface tension and high respiratory gas solubility of liquid PFC enable adequate oxygenation and carbon dioxide removal at low insufflation pressure. This work is aimed to determine by means of a mathematical simulation model the distribution of PFC pC^ and pCOs content in the lung and proposes a circuit set up for neonatal application. The results point out the possibility of using this new technique of liquid ventilation as an alternative to tradit

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