WIT Press

Model Clamp: A New Method To Study Electrical Interactions Between Cardiac Cells

Price

Free (open access)

Paper DOI

10.2495/BIO950191

Volume

2

Pages

8

Published

1995

Size

768 kb

Author(s)

R. Witters, E.E. Verheijck, R. Kumar, A.C.G. van Ginneken, R.W. Joyner & H.J. Jongsma

Abstract

The electrical impulse for the heartbeat is generated within the sinoatrial node and conducted to the working myocardium through gap junctions acting as low-resistance intercellular pathways. Single cells isolated from the sinoatrial node exhibit spontaneous electrical activity and are called pacemaker cells. These cells show a high degree of heterogeneity in their intrinsic electrical properties: there is, e.g., a large cell-to-cell difference in intrinsic interbeat interval. Nevertheless, they are synchr

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