WIT Press

Simulation Of The Dynamics Of Neuron Degeneration In Motor Neuron Disease

Price

Free (open access)

Paper DOI

10.2495/BIO950091

Volume

2

Pages

8

Published

1995

Size

583 kb

Author(s)

H.G. Lipinski & G. Kuther

Abstract

We designed a computer model of the dynamics of innervation and reinnervation of skeletal muscle fibers by motoneuronal networks representing a spinal motor nucleus. The model allowed to create motor units with different structures and arrangements. Motoneuron decay with different time courses was simulated by the aid of the Monte Carlo method. After a motoneuron was lost, denervation of the corresponding muscle fibers occurred followed by their reinnervation due to axonal sprouting. This simulation permits a quantitative analysis of the relations existing between the time course of motor neuron loss and muscle fiber denervation. 1 Introduction The time course of muscle

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