WIT Press

Mathematical Model For Shear-induced Cytosolic Calcium Oscillations: The Role Of (ca2+)i In Cytoskeleton Organisations

Price

Free (open access)

Paper DOI

10.2495/BIO950081

Volume

2

Pages

7

Published

1995

Size

655 kb

Author(s)

J.K. Chang, J. Kim, B.G. Min & D.C. Haif

Abstract

The inherent role of [Ca^+jj on the shear-induced polymerization of cytoskeleton was proposed by the flow chamber experiments and the mathematical modeling of cytosolic calcium oscillations to access the correlation of signal transduction and the mechanotransduction of endothelial cells. From the results of flow chamber experiments of endothelial cells adhered on the fibronectin, the opening characteristic of membrane-bound calcium channel was assumed to biphasic function to the exposure time of shear stress. With this modification, the model for IPs-induced calcium oscillation shows a good agreement with the wav

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