Author(s)

J.K. Chang, J. Kim, B.G. Min & D.C. Haif

Abstract

The inherent role of [Ca^+jj on the shear-induced polymerization of cytoskeleton was proposed by the flow chamber experiments and the mathematical modeling of cytosolic calcium oscillations to access the correlation of signal transduction and the mechanotransduction of endothelial cells. From the results of flow chamber experiments of endothelial cells adhered on the fibronectin, the opening characteristic of membrane-bound calcium channel was assumed to biphasic function to the exposure time of shear stress. With this modification, the model for IPs-induced calcium oscillation shows a good agreement with the wav

Keywords