Author(s)

M. Goni, H. Desimone, F. Clara & S. Urquiza

Abstract

A numerical solution of the inverse problem for parameter estimation of solute kinetics during hemodialysis based on a double pool model is presented. Weighted Least Squares Minimisation is employed to optimise the fit between data and estimated concentration of extracellular compartment, resulting in a non-linear set of equations where second order sensitivity parameters are involved in the solution process. The resulting systems of ordinary differential equations ( ODE ) are discretised by Finite Differences. Assuming the total distribution volume, estimation for volume ratio between intra-extracellular compartments, mass transfer coefficient of cellular membrane, dialyzer clearance

Keywords